Mohd Adil Shareef, Irfan Khan, Bathini Nagendra Babu and Ahmed Kamal* Pages 6864 - 6887 ( 24 )
Background: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents.
Objective: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness.
Method: Thorough literature review of all relevant papers and patents was conducted.
Conclusion: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.
Imidazo[2,1-b]thiazoles, pharmacological activities, therapeutic versatility, heterocycle, cytotoxic, antimicrobial.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002