K. Stewart and C. Abad-Zapatero Pages 941 - 948 ( 8 )
The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.
Candida Proteases,Antifungal Therapy,secreted acid proteases (SAP),Candida fungal species,fluconazole,echinocandin B,amphotericin,HIV PROTEASE INHIBITORS
, Department of Structural Biology, Abbott Laboratories, Abbott Park, IL 60064, USA.