Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Mohammad Jalali, Navid Jamali, Shahla Rezaei, Kamran Hessami, Pedram Keshavarz, Saeed Shahabi, Ali-Asghar Kolahi, Kristin Carson‐Chahhoud, Amirhossein Sahebkar and Saeid Safiri* Pages 840 - 852 ( 13 )
Background: A systematic review and meta-analysis of clinical trials were undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM).
Methods: Electronic databases such as PubMed, EMBASE, Scopus, Web of Science, Google Scholar, and Cochrane Central Register of Controlled Trials were searched from inception to 31 July 2019. Statistical heterogeneity was evaluated using Cochran’s Q test and I-square (I2) statistic. Data were pooled using random-effects models and weighted mean difference (WMD).
Results: From 1,733 citations, seven clinical trials were eligible for inclusion and meta-analysis. A significant reduction in hemoglobin A1c (HbA1c) (WMD -0.73; 95%CI -1.25 to -0.21; P= 0.006; I2= 72.2%) and body mass index (BMI) (WMD -0.55; 95%CI -1.03 to -0.07; P= 0.026; I2= 9.5%) was identified. However, no significant effect of diacerein intake was identified on fasting blood sugar (FBS) (WMD -9.00; 95%CI -22.57 to 4.57; P= 0.194; I2= 60.5%), homeostatic model assessment for insulin resistance (HOMA-IR) (WMD 0.39; 95%CI -0.95 to 1.73; P= 0.569; I2= 2.2%), body weight (WMD - 0.54; 95%CI -1.10 to 0.02; P= 0.059), triglycerides (WMD -0.56; 95%CI -24.16 to 23.03; P= 0.963; I2= 0.0%), total-cholesterol (WMD -0.21; 95%CI -12.19 to 11.78; P= 0.973; I2= 0.0%), HDL-cholesterol (WMD -0.96; 95%CI -2.85 to 0.93; P= 0.321; I2= 0.0%), and LDL-cholesterol levels (WMD -0.09; 95%CI -8.43 to 8.25; P= 0.983; I2= 37.8%).
Conclusion: Diacerein intake may reduce HbA1c and BMI; however, no evidence of the effect was observed for FBS, HOMA-IR, body weight, triglycerides, total cholesterol, HDL-cholesterol or LDLcholesterol.
Diacerein, diabetes mellitus, cardiometabolic, Meta-analysis, body weight, triglycerides.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Australian Centre for Precision Health, School of Health Sciences, University of South Australia, Adelaide, Halal Research Center of IRI, FDA, Tehran, Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz