Carla Petrella*, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi and Marco Fiore* Pages 7595 - 7613 ( 19 )
The Mediterranean diet is worldwide recognized as a good prototype of nutrition due to the conspicuous intake of olive oil, nuts, red wine, legumes, fruit, and vegetables, all fundamental elements rich in antioxidant substances and polyphenols. Polyphenols are a wide range of phytochemicals and/or synthetic chemical compounds with proven beneficial properties for human health. In the present review, we critically summarize the wellcharacterized antioxidant and anti-inflammatory properties of polyphenols contained in the olives and extra virgin olive oil and of resveratrol, a non-flavonoid phenolic compound. We discuss the potential use of these polyphenols as pharmaceutical formulations for the treatment of human diseases. We also show the emerging importance of their consumption in the prevention and management of crucial neurodegenerative conditions (alcohol-related brain disorders and aging) and in neuromuscular disorders (Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy), where oxidative stress plays a predominant role.
Olive polyphenols, resveratrol, microbiota, aging, alcohol-related brain disorders, SMA, ALS, DMD.
Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome, Department of Sense Organs, Medical Faculty, Sapienza University of Rome, Rome, Department of Sense Organs, Medical Faculty, Sapienza University of Rome, Rome, Department of Odontostomatological and Maxillofacial Sciences, Sapienza University of Rome, Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome, Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome, ASUR Marche, AV4, Ancona, Department of Experimental Medicine, Sapienza University of Rome, Rome, Sitac, Societa’ Italiana per lo Studio Delle Patologie Alcool Derivate. Rome, Department of Experimental Medicine, Sapienza University of Rome, Rome, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Institute of Biochemistry and Cell Biology, Section of Neurobiology, (IBBC-CNR), Rome