Alyson Curry, Dawanna White and Yana Cen* Pages 1718 - 1738 ( 21 )
Nicotinamide adenine dinucleotide (NAD+) is a key player in many metabolic pathways as an activated carrier of electrons. In addition to being the cofactor for redox reactions, NAD+ also serves as the substrate for various enzymatic transformations such as adenylation and ADP-ribosylation. Maintaining cellular NAD+ homeostasis has been suggested as an effective anti-aging strategy. Given the importance of NAD+ in regulating a broad spectrum of cellular events, small molecules targeting NAD+ metabolism have been pursued as therapeutic interventions for the treatment of mitochondrial disorders and agerelated diseases. In this article, small molecule regulators of NAD+ biosynthetic enzymes will be reviewed. The focus will be given to the discovery and development of these molecules, the mechanism of action as well as their therapeutic potentials.
Nicotinamide adenine dinucleotide (NAD +), metabolic pathways, electrons, redox reactions, enzymatic transformations,therapeutic potentials.
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23219