Syed N.A. Bukhari*, Michael A. Tandiary, Mohammad M. Al-Sanea, Mohamed A. Abdelgawad, Chin F. Chee and Muhammad A. Hussain Pages 2995 - 3027 ( 33 )
LIMK1 and LIMK2 are involved in the regulation of cellular functions that depend on the dynamics of actin cytoskeleton. Disregulation of LIM kinases has been associated with diseases, such as tumor progression and metastasis, viral infection, and ocular diseases. Motivated by this, numerous studies have been carried out to discover small organic molecules capable of inhibiting LIM kinase effectively and selectively. In this review, a comprehensive survey of small organic molecules for LIM kinase inhibitors is reported, together with SAR study results, and the synthesis of these inhibitors.
Cytoskeleton, thiazole, thienopyridine derivatives, thienopyrimidine, synthesis, LIM kinase.
Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Nanotechnology and Catalysis Research Centre, University of Malaya, 50603 Kuala Lumpur, Institute of Chemistry, University of Sargodha, Sargodha