Daljeet Singh Dhanjal, Sonali Bhardwaj, Chirag Chopra, Reena Singh*, Jiri Patocka, Bohumir Plucar, Eugenie Nepovimova, Martin Valis and Kamil Kuca* Pages 2632 - 2651 ( 20 )
Autism is a neurodevelopmental disorder belonging to the autism spectrum disorder (ASD). In ASDs, the individuals show substantial impairments in social communication, repetitive behaviours, and sensory behaviours deficits in the early stages of their life. Globally, the prevalence of autism is estimated to be less than 1%, especially in high- -income countries. In recent decades, there has been a drastic increase in the incidence of ASD, which has put ASD into the category of epidemics. Presently, two US Food and Drug Administration-approved drugs, aripiprazole and risperidone, are used to treat symptoms of agitation and irritability in autistic children. However, to date, no medication has been found to treat the core symptoms of ASD. The adverse side effects of conventional medicine and limited treatment options have led families of autistic children to turn to complementary and alternative medicine (CAM) treatments, which are perceived as relatively safe compared to conventional medicine. Recently N, N-dimethylglycine (DMG), a dietary supplement, has emerged as a useful supplement to improve the mental and physical state of children with ASD. The current review discusses ASD, the prevalence of ASD, the CAM approach, and the efficacy of CAM treatment in children with ASD. Moreover, it highlights the chemistry, pharmacological effect, and clinical studies of DMG, highlighting its potential for improving the lifestyle of children with ASD.
Dimethylglycine, pharmacology, autism spectrum disorders (ASD), complementary and alternative medicine (CAM), central nervous system (CNS), neurological disorders.
Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Department of Microbiology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Department of Radiology, Toxicology and Population Protection, Faculty of Health and Social Studies, University of South Bohemia in Ceske Budejovice, Reflex Therapy Laboratory, Udolni 393/18, 602 00 Brno, Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove