S. Furst*, S. Hosztafi and T. Friedmann Pages 423 - 440 ( 18 )
This paper surveys the relationships between the chemical structures and pharmacological activities of natural or semisynthetic 4,5a epoxymorphinans, synthetic morphinans and benzomorphans. Substitution . of the N-methyl group affords strong analgesics, opioid antagonists and mixed agonist-antagonists respectively. The role of opioid agonists and antagonists in the development of opioid receJ:>tor models is also discussed.