Diego Geroldi, Colomba Falcone and Enzo Emanuele Pages 1971 - 1978 ( 8 )
The receptor for advanced glycation end products (RAGE) is a cell-bound receptor of the immunoglobulin superfamily which may be activated by a variety of proinflammatory ligands including advanced glycoxidation end products, S100/calgranulins, high mobility group box 1, and amyloid β-peptide. RAGE has a secretory splice isoform, soluble RAGE (sRAGE), that lacks the transmembrane domain and therefore circulates in plasma. By competing with cell-surface RAGE for ligand binding, sRAGE may contribute to the removal/neutralization of circulating ligands thus functioning as a decoy. Clinical studies have recently shown that higher plasma levels of sRAGE are associated with a reduced risk of coronary artery disease, hypertension, the metabolic syndrome, arthritis and Alzheimers disease. Increasing the production of plasma sRAGE is therefore considered to be a promising therapeutic target that has the potential to prevent vascular damage and neurodegeneration. This review presents the state of the art in the use of sRAGE as a disease marker and discusses the therapeutic potential of targeting sRAGE for the treatment of inflammationrelated diseases such as atherosclerosis, arthritis and Alzheimers disease.
receptor for advanced glycation end products,inflammation,neurodegeneration,atherosclerosis,metabolic,syndrome,hypertension,arthritis,Alzheimer's disease,biomarker
, , Department of Internal Medicine and Medical Therapeutics, IRCCS San Matteo Hospital, Malattie Vascolari e Metaboliche, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.