Lian-Ping He, Cui-Ping Li, Chang-Wei Liu* and Wei Gu* Pages 1 - 10 ( 10 )
Increasing evidence suggests that vitamin D is one of the causes of accelerated development of Insulin Resistance (IR) and islet cell secret dysfunction. Numerous studies have shown that vitamin D can reduce inflammation, activate the transcription of the insulin receptors and related genes, and increase insulin-mediated glucose transport, thereby reducing IR. This article reviews the molecular mechanisms related to vitamin D deficiency and pancreatic β-cell dysfunction in patients with Type 2 Diabetes (T2D).
Vitamin D, Insulin resistance (IR), Oxidative stress, Type 2 diabetes mellitus(T2D), Ca2+ signaling pathway, inflammatory cytokines.