Alaa A. A. Aljabali*, Rasha M. Bashatwah, Mohamed El-Tanani and Murtaza M. Tambuwala Pages 1 - 42 ( 42 )
The investigation of naturally derived anticancer drugs has gained prominence in cancer therapy research. Within a broad context, this review seeks to elucidate the molecular foundations and diverse mechanisms underlying these compounds to understand their pivotal role in advancing effective interventions. Additionally by employing a systematic approach, this study examined the interplay between cellular components, signaling pathways, and genetic factors, providing valuable insights into the regulatory networks governing the efficacy of these drugs. Categorization based on sources (plants, animals, marine organisms, and microbes) revealed unique bioactive constituents and therapeutic potential. Mechanistic investigations have revealed the ability of these compounds to induce apoptosis, inhibit angiogenesis, modulate metabolic processes, stimulate the immune system, and arrest the cell cycle. This overview encompasses both approved drugs and those undergoing clinical trials, highlighting their heightened efficacy and reduced toxicity compared to their synthetic counterparts. However, challenges persist in terms of standardization, quality control, and large-scale production. In conclusion, this review examined the potential of naturally derived anticancer drugs to contribute to advancements in cancer treatment and enhance patient outcomes. In addition to their effectiveness, natural anticancer drugs are generally less toxic and have fewer harmful side effects than conventional chemotherapies. This emphasizes the need for continued research, collaborative efforts, and addressing the regulatory and intellectual property challenges associated with natural products. This review provides a balanced perspective on the mechanisms, advantages, and prospects.
Natural anticancer drugs, mechanisms of action, cancer therapy, combination therapy, personalized medicine, synergistic effect.