D. Gambino Pages 3616 - 3631 ( 16 )
Medicinal Inorganic Chemistry offers the high diversity of metal coordination chemistry for the development of bioactive compounds for therapeutic or diagnostic medicinal purposes. The design of novel metal-based antitumor agents occupies a privileged position in this discovery process. On the other hand, the research on metal-based radiopharmaceuticals for therapy and imaging is a subarea of high priority and development. This review describes therapeutic applications of metal compounds directed towards hypoxic tissues. Strategies in the search for new bioreductive metal-based prodrugs will be discussed. In addition, approaches for the imaging of hypoxic tissues by using metal radionuclides will be exemplified.
Hypoxia selectivity,metal-based compounds,bioreduction,bioreductive metal-based prodrugs,nitrogen mustards,aromatic N-oxides,quinoxalines and thiosemicarbazones metal complexes,Hypoxic Tissues,diagnostic medicinal purposes,medicinal purposes,solubility,lipophilicity,activation by bioreduction,magnetic resonance imaging (MRI),antitumoral activity of cisplatin,metal-based anticancer drugs,anticancer chemotherapy,organic chemotherapeutics,promoting metastasis and angiogenesis,slow-growing hypoxic solid tumors,hypoxia-selective cytotoxins,conventional antitumoral drugs,nitroaromatics,labile high-spin Co(II) octahedral complexes,sta-ble Co(II) hexaaquo species,bidentate ali-phatic nitrogen mustards,aerobic cytotoxicity,aziridine complexes,hypoxia selective cytotoxins,aliphatic mustards,polyazamacrocyclic nitrogen mustards,Nitrogen mustard ligands,bioreductive prodrugs,tetradentate polyazamacrocyclic nitrogen,pyrrolo[3,2-f]quinoline analogues,quantitative radiolytic,animal metastatic foci,redox cycling process,superoxide forma-tion,antecedent,Tirapazamine,bioreduction and radiotherapy,Chemo preventive,anti-tumor effects,vanadium-prodrug complex,normoxia,hypoxia,superoxide dismutase activity,Tirapazamine [62],Mitomycine C,Misonidazole,electrochemical behavior,hydrophilic solvents,Metal-Radionuclide Radiopharmaceuti-cals,diabetic retinopathy,radiodiagnosis,radiotherapy purposes,techniques gamma scintigraphy,annihilation radiation,Cu-bis(thiosemicarbazone) complexes,myocardium,potential radiotherapeutic agent,rapid acid-catalyzed dissociation,subsequent back-oxidation,PET tracers,necrotic tissue,hypoxia-selective nitroimidazoles,amineoxime-type chelators,non nitro-aryl-based ra-diotracer,novel potential hy-poxic-tissue tracers,Bioreduced in Biological Media,activated by bioreduction,chelating bioligands,antitumor agents,cisplatin,carboplatin,oxaliplatin,2-methyl-5-nitro-imidazole derivatives,PnAO -1-(2-nitroimidazole),PnAO-5-0xa-6-(2-nitroimidazole),Pt(IV) complexes reduction potentials,anticancer agents,hypoxic solid tumors
Catedra de Quimica Inorganica, Facultad de Quimica, Universidad de la Republica, Montevideo, Uruguay.