M. Galan, J. Sanchez-Rodriguez, M. Cangiotti, S. Garcia-Gallego, J.L. Jimenez, R. Gomez, M.F. Ottaviani, M.A. Munoz-Fernandez and F.J. de la Mata Pages 4984 - 4994 ( 11 )
We describe here the use of anionic carbosilane dendrimers to obtain new copper complexes. UV-Vis and a computer aided analysis of the EPR spectra provided information about the coordination modes of copper depending on the nature of the dendrimer and about the geometry and structure of the complexes in solution. Some of these metallo-dendrimers have been tested “in vitro” as antiviral compounds in the inhibition of HIV infection in pre and post-infection treatment.
Anionic, antiviral properties, carboxylate, copper, dendrimers, EPR, HIV, microbicide, sulfonate, transition-metal ions
, , , , , , , , Departamento de Quimica Inorganica, Universidad de Alcala, Campus Universitario. Edificio de Farmacia, 28871 Alcala de Henares. Spain.