Marlein Miranda Cona, Raymond Oyen and Yicheng Ni Pages 1829 - 1849 ( 21 )
Necrosis is an in vivo chaotic event distinguished by uncontrolled disintegration of the cell membrane leading to cytolysis, inflammation and tissue destruction followed by a healing or regenerating process. Targeting necrosis may offer potential diagnostic, therapeutic and/or theragnostic applications in translational medicine. This article reviews the current concept of necrosis including definition, etiology and pathophysiology. The evolution and development of a wide diversity of necrosis targeting agents and their potential applications in preclinical and clinical settings are also elaborated and discussed.
Cancer, cardiovascular diseases, diagnosis, necrosis, necrosis avid compounds, treatment.
, , University Hospitals, K.U. Leuven, Belgium.