Salvatore Genovese, Serena Fiorito, Francesco Epifano and Vito Alessandro Taddeo Pages 3426 - 3433 ( 8 )
O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.
Anthraquinones, cancer, chalcones, cinnamic acids, coumarins, diketopiperazines, oxyprenylated secondary metabolites.
Department of Pharmacy, University “G. d’Annunzio” of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.