Jerzy Leszek, Elżbieta Trypka, Euphrosyni Koutsouraki, Dimitrios Michmizos, Nagendra Sastry Yarla, Vadim V. Tarasov, Ghulam Md Ashraf and Gjumrakch Aliev* Pages 5389 - 5394 ( 6 )
A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings. The close association of LLD with cognitive impairment is now well documented and evidenced. However, it is still not clear whether it is depression that leads to cognitive decline, and in more severe cases, to dementia. The work presented in this review article suggests that depression and dementia frequently and strongly copresent, even if the causality remains largely opaque.
Aging, Alzheimer disease, depression, dementia, BDNF late-life depression.
Department of Psychiatry, Wroclaw Medical University, Pasteura 10, Str.,50-368 Wroclaw, Department of Psychiatry, Wroclaw Medical University, Pasteura 10, Str.,50-368 Wroclaw, Medical School, Aristotle University, Thessaloniki, Medical School, Aristotle University, Thessaloniki, Department of Biochemistry and Bioinformatics, Institute of Science, GITAM University, Visakhapatnam, Andhra Pradesh, 530045, Sechenov First Moscow State Medical University, 119991, Moscow, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Sechenov First Moscow State Medical University, 119991, Moscow