Jean-Michel Kauffmann*, Nurgul K. Bakirhan, Burcin Bozal-Palabiyik, Bengi Uslu, Rocio Rodriguez Gomez, Marie Vandeput and Sibel A. Ozkan Pages 4050 - 4065 ( 16 )
Liquid chromatography (LC) coupled to an electrochemical (EC) detector is a complementary analytical tool compared to LC coupled with optical or mass spectrometry detectors (LC-MS). LC-EC can be applied to the determination of molecules difficult to be analyzed by other commercially available detectors. New EC detector design and new working electrode material have extended the scope of application in the field of pharmaceutical compounds analysis. Combining EC with LC-MS offers additional advantages compared to optical detectors in terms of drug stability and drug metabolism mimicry studies. Selected literature devoted to pharmacologically active compounds in their dosage forms, herbal drugs in natural products, drug residues in feed and/or in biological samples are reported in this review.
Liquid chromatography, electrochemical detector, biomedical, pharmaceutical analysis, bioanalysis, amperometry.
Universite Libre de Bruxelles (ULB), Faculty of Pharmacy, Campus Plaine CP 205/6, 1050 Brussels, Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan, Ankara, Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan, Ankara, Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan, Ankara, University of Granada, Faculty of Science, Department of Analytical Chemistry, E-18071 Granada, Universite Libre de Bruxelles (ULB), Faculty of Pharmacy, Campus Plaine CP 205/6, 1050 Brussels, Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06100 Tandogan, Ankara