S. P. Gupta and A. N. Nagappa Pages 1779 - 1794 ( 16 )
A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds, hydrazides and amides, tetracyclines, and depsides and depsidones. For all these compounds, the important structural features essential for the inhibition of the integrase are pointed out.
integrase inhibitors,hiv-1 integrase,oligonucleotides,double-stranded
, Department of Chemistry, Birla Institute of Technology and Science, Pilani - 333 031, India.