Samira Hosseini*, Rodrigo B. Muñoz-Soto, Jacqueline Oliva-Ramírez, Patricia Vázquez-Villegas, Nasrin Aghamohammadi, Aida Rodriguez-Garcia* and Sergio O. Martinez-Chapa Pages 719 - 744 ( 26 )
In this paper, we review the history of Dengue, the mechanism of infection, the molecular characteristics and components of Dengue, the mechanism of entry to the target cells, cyclization of the genome and replication process, as well as translation of the proteins for virus assembly. The major emphasis of this work is on natural products and plant extracts, which were used for as palliative or adjuvant treatment of Dengue. This review article also summarizes the latest findings in regards to the marine products as effective drugs to target different symptoms of Dengue. Furthermore, an update on synthetic drugs for treating Dengue is provided in this review. As a novel alternative, we describe monoclonal antibody therapy for Dengue management and treatment.
Natural plant extracts, dengue treatment, marine products, synthetic agents for treatment of dengue, drugs, monoclonal antibody therapy.
Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, N.L. 64849, Tecnologico de Monterrey, Campus Ciudad de México, Escuela de Ingeniería y Ciencias, Calle del Puente 222, Mexico City, Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Ave. Lago de Guadalupe Km 3.5, Cd Lopez Mateos, Atizapan, Estado de Mexico, Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, N.L. 64849, Centre for Occupational and Environmental Health, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Universidad Autonoma de Nuevo Leon, Facultad de Ciencias Biologicas, Instituto de Biotecnología. Ave. Pedro de Alba S/N, Ciudad Universitaria, San Nicolás de los Garza, N.L. 66455, Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, N.L. 64849