Carmelo Puglia*, Rosario Pignatello, Virginia Fuochi, Pio Maria Furneri, Maria Rosaria Lauro, Debora Santonocito, Rita Cortesi and Elisabetta Esposito Pages 4681 - 4696 ( 16 )
Phytochemicals represent an important class of bioactive compounds characterized by significant health benefits. Notwithstanding these important features, their potential therapeutic properties suffer from poor water solubility and membrane permeability limiting their approach to nutraceutical and pharmaceutical applications. Lipid nanoparticles are well known carrier systems endowed with high biodegradation and an extraordinary biocompatible chemical nature, successfully used as platform for advanced delivery of many active compounds, including the oral, topical and systemic routes. This article is aimed at reviewing the last ten years of studies about the application of lipid nanoparticles in active natural compounds reporting examples and advantages of these colloidal carrier systems.
Solid lipid nanoparticles, nanostructured lipid carriers, active natural compounds, drug delivery, stability, carrier systems.
Department of Drug Sciences, University of Catania, Catania, Department of Drug Sciences, University of Catania, Catania, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Department of Pharmacy, University of Salerno, Fisciano (SA), Department of Drug Sciences, University of Catania, Catania, Department of Life Sciences and Biotechnologies, University of Ferrara, Ferrara, Department of Life Sciences and Biotechnologies, University of Ferrara, Ferrara